ERCC6L Antibody

Polyclonal Antibody

ERCC6L

ATP dependent helicase ERCC6 like antibody, ATP-dependent helicase ERCC6-like antibody, DNA excision repair protein ERCC 6 like antibody, DNA excision repair protein ERCC-6-like antibody, ERC6L_HUMAN antibody, ERCC 6L antibody, Ercc6l antibody, Excision repair cross complementing rodent repair deficiency complementation group 6 like antibody, Excision repair protein ERCC6 like antibody, FLJ20105 antibody, MGC131695 antibody, PICH antibody, Plk1 interacting checkpoint helicase antibody, PLK1-interacting checkpoint helicase antibody, SNF2/RAD54 family protein antibody, Tumor antigen BJ HCC 15 antibody, Tumor antigen BJ-HCC-15 antibody

Fusion protein of human ERCC6L

PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1, 250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.

Antigen Affinity Purified

Cell Biology

Fusion protein of Human ERCC6L