PLAU Antibody

Polyclonal Antibody

PLAU

ATF antibody, ATF uPA antibody, BDPLT5 antibody, Plasminogen activator antibody, Plasminogen activator urinary antibody, Plasminogen activator urokinase antibody, PLAU antibody, QPD antibody, u PA antibody, U plasminogen activator antibody, u-PA antibody, U-plasminogen activator antibody, uPA antibody, URK antibody, UROK_HUMAN antibody, Urokinase plasminogen activator antibody, Urokinase type plasminogen activator antibody, Urokinase type plasminogen activator precursor antibody, Urokinase-type plasminogen activator chain B antibody

Fusion protein of human PLAU

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Antigen Affinity Purified

Cardiovascular

Fusion protein of Human PLAU