ATR Antibody

ArtNr	CSB-PA622666LA01HU-50ug
Hersteller	Cusabio
Menge	50 ug
Quantity options	100 ug 20 ug 50 ug
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ataxia telangiectasia and Rad3 related antibody,Ataxia telangiectasia and Rad3-related protein antibody,ATR antibody,ATR_HUMAN antibody,FCTCS antibody,FRAP Related Protein 1 antibody,FRAP-related protein 1 antibody,FRP1 antibody,MEC1 antibody,MEC1 mitosis entry checkpoint 1 homolog antibody,Protein kinase ATR antibody,RAC3 antibody,Rad3 related protein antibody,SCKL antibody,SCKL1 antibody,Serine/threonine protein kinase ATR antibody,Serine/threonine-protein kinase ATR antibody
Similar products	ATR, FRP1, Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200
Manufacturer - Targets	ATR
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Manufacturer - Alias	Ataxia telangiectasia and Rad3 related antibody, Ataxia telangiectasia and Rad3-related protein antibody, ATR antibody, ATR_HUMAN antibody, FCTCS antibody, FRAP Related Protein 1 antibody, FRAP-related protein 1 antibody, FRP1 antibody, MEC1 antibody, MEC1 mitosis entry checkpoint 1 homolog antibody, Protein kinase ATR antibody, RAC3 antibody, Rad3 related protein antibody, SCKL antibody, SCKL1 antibody, Serine/threonine protein kinase ATR antibody, Serine/threonine-protein kinase ATR antibody
Immunogen Species	Human
Immunogen	Recombinant Human Serine/threonine-protein kinase ATR protein (2405-2644AA)
Dilution	ELISA:1:2000-1:10000 WB:1:500-1:5000 IHC:1:20-1:200
Background	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method	>95%, Protein G purified
General Research Areas	Epigenetics and Nuclear Signaling
Initial Research Areas	Epigenetics and Nuclear Signaling
Antigen Species	Human
Antigen	Recombinant Human Serine/threonine-protein kinase ATR protein (2405-2644AA)
Clonality	Polyclonal

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Menge: 50 ug

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Lieferung vsl. bis 25.12.2025

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