TET2 Antibody

ArtNr	CSB-PA764560ESR1HU-50ul
Hersteller	Cusabio
Menge	50 ul
Quantity options	100 ul 50 ul
Kategorie	Oncology Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	FLJ20032 antibody,KIAA1546 antibody,MDS antibody,Methylcytosine dioxygenase TET2 antibody,Nbla00191 antibody,Probable methylcytosine dioxygenase TET2 antibody,Protein Ayu17 449 antibody,Tet 2 antibody,Tet methylcytosine dioxygenase 2 antibody,Tet oncogene 2 antibody,Tet oncogene family member 2 antibody,TET2 antibody,TET2_HUMAN antibody
Similar products	TET2, KIAA1546, Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Manufacturer - Targets	TET2
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Manufacturer - Alias	FLJ20032 antibody, KIAA1546 antibody, MDS antibody, Methylcytosine dioxygenase TET2 antibody, Nbla00191 antibody, Probable methylcytosine dioxygenase TET2 antibody, Protein Ayu17 449 antibody, Tet 2 antibody, Tet methylcytosine dioxygenase 2 antibody, Tet oncogene 2 antibody, Tet oncogene family member 2 antibody, TET2 antibody, TET2_HUMAN antibody
Immunogen Species	Human
Immunogen	Recombinant Human Methylcytosine dioxygenase TET2 protein (1833-2002AA)
Dilution	ELISA:1:2000-1:10000 IHC:1:20-1:200
Background	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method	Antigen Affinity Purified
General Research Areas	Epigenetics and Nuclear Signaling
Initial Research Areas	Epigenetics and Nuclear Signaling
Antigen Species	Human
Antigen	Recombinant Human Methylcytosine dioxygenase TET2 protein (1833-2002AA)
Clonality	Polyclonal

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