BAP1 Antibody

Polyclonal Antibody

BAP1

BAP 1 antibody, Bap1 antibody, BAP1_HUMAN antibody, BRCA 1 associated protein 1 antibody, BRCA1 associated protein 1 antibody, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) antibody, BRCA1-associated protein 1 antibody, Cerebral protein 13 antibody, Cerebral protein 6 antibody, DKFZp686N04275 antibody, FLJ35406 antibody, FLJ37180 antibody, HUCEP 13 antibody, Hucep 6 antibody, HUCEP13 antibody, Hucep6 antibody, KIAA0272 antibody, TPDS antibody, Ubiquitin carboxy terminal hydrolase antibody, Ubiquitin carboxyl terminal hydrolase BAP 1 antibody, Ubiquitin carboxyl terminal hydrolase BAP1 antibody, Ubiquitin carboxyl-terminal hydrolase BAP1 antibody, UCHL2 antibody

Recombinant Human Ubiquitin carboxyl-terminal hydrolase BAP1 protein (460-729AA)

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.

Antigen Affinity Purified

Cell Biology

Recombinant Human Ubiquitin carboxyl-terminal hydrolase BAP1 protein (460-729AA)