CACNA1A Antibody

Polyclonal Antibody

CACNA1A

CACNA1A antibody, CACH4 antibody, CACN3 antibody, CACNL1A4 antibody, Voltage-dependent P/Q-type calcium channel subunit alpha-1A antibody, Brain calcium channel I antibody, BI antibody, Calcium channel antibody, L type antibody, alpha-1 polypeptide isoform 4 antibody, Voltage-gated calcium channel subunit alpha Cav2.1 antibody

Synthetic peptide of human CACNA1A

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.

Antigen Affinity Purified

Neuroscience

Synthetic peptide of Human CACNA1A