PTPN13 Antibody

Polyclonal Antibody

PTPN13

PTPN13 antibody, PNP1 antibody, PTP1E antibody, PTPL1 antibody, Tyrosine-protein phosphatase non-receptor type 13 antibody, EC 3.1.3.48 antibody, Fas-associated protein-tyrosine phosphatase 1 antibody, FAP-1 antibody, PTP-BAS antibody, Protein-tyrosine phosphatase 1E antibody, PTP-E1 antibody, hPTPE1 antibody, Protein-tyrosine phosphatase PTPL1 antibody

Synthetic peptide of human PTPN13

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Antigen Affinity Purified

Cell Biology

Synthetic peptide of Human PTPN13