RFFL Antibody

Polyclonal Antibody

RFFL

CARP-2 antibody, CARP2 antibody, Caspase regulator CARP2 antibody, Caspases 8 and 10 associated RING finger protein 2 antibody, caspases-8 and -10- associated RING finger protein 2 antibody, Caspases-8 and -10-associated RING finger protein 2 antibody, E3 ubiquitin protein ligase rififylin antibody, E3 ubiquitin-protein ligase rififylin antibody, Fring antibody, FYVE RING finger protein Sakura antibody, FYVE-RING finger protein Sakura antibody, Rffl antibody, RFFL_HUMAN antibody, Rififylin antibody, RING finger and FYVE like domain containing protein antibody, RING finger and FYVE-like domain-containing protein 1 antibody, RING finger protein 189 antibody, RING finger protein 34 like antibody, RING finger protein 34-like antibody, RNF189 antibody, RNF34L antibody

Fusion protein of human RFFL

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.

Antigen Affinity Purified

Cell Biology

Fusion protein of Human RFFL