FGFR1 Antibody

Polyclonal Antibody

FGFR1

Basic fibroblast growth factor receptor 1 antibody, bFGF-R-1 antibody, BFGFR antibody, CD331 antibody, CEK antibody, FGFBR antibody, FGFR 1 antibody, FGFR-1 antibody, FGFR1 antibody, FGFR1/PLAG1 fusion antibody, FGFR1_HUMAN antibody, fibroblast growth factor receptor 1 antibody, FLG antibody, FLT-2 antibody, FLT2 antibody, Fms-like gene antibody, Fms-like tyrosine kinase 2 antibody, fms-related tyrosine kinase 2 antibody, HBGFR antibody, heparin-binding growth factor receptor antibody, HH2 antibody, HRTFDS antibody, hydroxyaryl-protein kinase antibody, KAL2 antibody, N-SAM antibody, OGD antibody, Proto-oncogene c-Fgr antibody

Fusion protein of human FGFR1

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized.

Antigen Affinity Purified

Cardiovascular

Fusion protein of Human FGFR1