CDK4 Antibody

Polyclonal Antibody

CDK4

Cdk 4 antibody, cdk4 antibody, CDK4 protein antibody, CDK4_HUMAN antibody, Cell division kinase 4 antibody, Cell division protein kinase 4 antibody, CMM 3 antibody, CMM3 antibody, Crk3 antibody, Cyclin dependent kinase 4 antibody, Cyclin-dependent kinase 4 antibody, Melanoma cutaneous malignant 3 antibody, MGC14458 antibody, p34 cdk4 antibody, PSK J3 antibody, PSK-J3 antibody

Fusion protein of human CDK4

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Antigen Affinity Purified

Cell Biology

Fusion protein of Human CDK4