CALR Antibody

Polyclonal Antibody

CALR

Autoantigen RO antibody, CALR antibody, CALR protein antibody, CALR_HUMAN antibody, Calregulin antibody, Calreticulin antibody, cC1qR antibody, CRP55 antibody, CRT antibody, CRTC antibody, Endoplasmic reticulum resident protein 60 antibody, Epididymis secretory sperm binding protein Li 99n antibody, ERp60 antibody, FLJ26680 antibody, grp60 antibody, HACBP antibody, HEL S 99n antibody, RO antibody, Sicca syndrome antigen A (autoantigen Ro, calreticulin) antibody, Sicca syndrome antigen A antibody, SSA antibody

Fusion protein of human CALR

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.

Antigen Affinity Purified

Tags & Cell Markers

Fusion protein of Human CALR