Recombinant Human Cytochrome c(CYCS)

N-terminal GST-tagged

38.6 kDa

Electron carrier protein. The oxidized form of the cytochrome c he group can accept an electron from the he group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti-apoptotic mbers or activation of the pro-apoptotic mbers of the Bcl-2 family leads to altered mitochondrial mbrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.

Mitochondrion intermembrane space

p53signalingpathway

Full Length of Mature Protein

Tris-based buffer, 50% glycerol