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Recombinant Human PC4 and SFRS1-interacting protein(PSIP1)

Recombinant Human PC4 and SFRS1-interacting protein(PSIP1)

Hersteller	Cusabio
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Menge	500ug
Host	E.coli
ArtNr	CSB-EP018860HU-500
eClass 6.1	34160400
eClass 9.0	42020190
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Research areas	Immunology
Target / Protein	PSIP1
Biologically active	Not Test
Expression system	E.coli
Species of origin	Homo sapiens (Human)
Uniprot ID	O75475
AA Sequence	MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKP PTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGK PNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNAS SDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDIT TPKAARRGRKRKAEKQVETEEAGVVTTATASVNLK VSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDI ITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPR KEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGD DQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRK RKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDS RLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQV TMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANK TKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQP QHNGESNEDSKDNHEASTKKKPSSEERETEISLKD STLDN
Tag Info	N-terminal 6xHis-SUMO-tagged
Expression Region	1-530aa
Protein length	Full Length
MW	76.1 kDa
Alternative Name(s)	CLL-associated antigen KW-7Dense fine speckles 70 kDa protein ; DFS 70Lens epithelium-derived growth factorTranscriptional coactivator p75/p52
Relevance	Transcriptional coactivator involved in neuroepithelial st cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
References	Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation.Ge H., Si Y., Roeder R.G.EMBO J. 17:6723-6729(1998)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Involvement in disease	A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9; 11)(p22; p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4.
Subcellular Location	Nucleus
Protein Families	HDGF family
Tissue Specificity	Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
Tag Information	N-terminal 6xHis-SUMO-tagged

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