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Recombinant Human Prefoldin subunit 5(PFDN5)

Recombinant Human Prefoldin subunit 5(PFDN5)

Hersteller	Cusabio
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Menge	200ug
Host	E.coli
ArtNr	CSB-RP014144h-200
eClass 6.1	34160400
eClass 9.0	42020190
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Research Topic	Epigenetics and Nuclear Signaling
Uniprot ID	Q99471
Gene Names	PFDN5
Organism	Homo sapiens (Human)
AA Sequence	AQSINITELNLPQLEMLKNQLDQEVEFLSTSIAQL KVVQTKYVEAKDCLNVLNKSNEGKELLVPLTSSMY VPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRK IDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQ LTALGAAQATAKA
Expression Region	2-154aa
Sequence Info	Full Length of Mature Protein
Source	E.coli
Tag Info	N-terminal GST-tagged
MW	44.2 kDa
Alternative Name(s)	C-Myc-binding protein Mm-1Myc modulator 1
Relevance	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.
Reference	MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc.Mori K., Maeda Y., Kitaura H., Taira T., Iguchi-Ariga S.M., Ariga H.J. Biol. Chem. 273:29794-29800(1998)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.
Subcellular Location	Isoform 1: Nucleus, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Nucleus
Protein Families	Prefoldin subunit alpha family
Tissue Specificity	Highly expressed in pancreas and skeletal muscle and moderately in other tissues.

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