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Recombinant Human Thioredoxin(TXN)

Recombinant Human Thioredoxin(TXN)

Hersteller	Cusabio
Kategorie	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins Neuronal Cell Markers
Typ	Proteins Recombinant
Specific against	other
Menge	200ug
Host	E.coli
ArtNr	CSB-RP028144h-200
eClass 6.1	34160400
eClass 9.0	42020190
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Research areas	Transport
Target / Protein	TXN
Biologically active	Not Test
Expression system	E.coli
Species of origin	Homo sapiens (Human)
Uniprot ID	P10599
AA Sequence	VKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCK MIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEV KCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
Tag Info	N-terminal GST-tagged
Expression Region	2-105aa
Protein length	Full Length of Mature Protein
MW	38.6 kDa
Alternative Name(s)	ATL-derived factor ; ADFSurface-associated sulphydryl protein ; SASP
Relevance	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
References	Cloning and expression of a cDNA for human thioredoxin.Wollman E.E., D'Auriol L., Rimsky L., Shaw A., Jacquot J.-P., Wingfield P., Graber P., Dessarps F.J. Biol. Chem. 263:15506-15512(1988)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.; FUNCTION
Subcellular Location	Nucleus, Cytoplasm, Secreted
Protein Families	Thioredoxin family
Paythway	NOD-likereceptorsignalingpathway

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