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Recombinant Human Profilin-1(PFN1)

Recombinant Human Profilin-1(PFN1)

Hersteller	Cusabio
Kategorie	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Format	Liquid
Menge	200ug
Host	E.coli
ArtNr	CSB-RP041544h-200
eClass 6.1	34160400
eClass 9.0	42020190
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Research areas	Neuroscience
Target / Protein	PFN1
Biologically active	Not Test
Expression system	E.coli
Species of origin	Homo sapiens (Human)
Uniprot ID	P07737
AA Sequence	AGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVP GKTFVNITPAEVGVLVGKDRSSFYVNGLTLGGQKC SVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKT DKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
Tag Info	N-terminal GST-tagged
Expression Region	2-140aa
Protein length	Full Length of Mature Protein
MW	41.9 kDa
Alternative Name(s)	Epididymis tissue protein Li 184aProfilin I
Relevance	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
References	Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis.Kwiatkowski D.J., Bruns G.A.P.J. Biol. Chem. 263:5910-5915(1988)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Involvement in disease	Amyotrophic lateral sclerosis 18 (ALS18)
Subcellular Location	Cytoplasm, cytoskeleton
Protein Families	Profilin family
Tissue Specificity	Expressed in epididymis (at protein level).
Paythway	Regulationofactincytoskeleton

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