Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Menge |
1mg |
Host |
E.coli |
ArtNr |
CSB-RP049644h-1 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Research Areas |
Cell Biology |
Uniprot ID |
Q9H0A8 |
Gene Names |
COMMD4 |
Organism |
Homo sapiens (Human) |
AA Sequence |
MRFRFCGDLDCPDWVLAEISTLAKMSSVKLRLLCS QVLKELLGQGIDYEKILKLTADAKFESGDVKATVA VLSFILSSAAKHSVDGESLSSELQQLGLPKEHAAS LCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDY TLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMS LSADKFQVLLAELKQAQTLM |
Expression Region |
1-195aa |
Sequence Info |
Partial |
Source |
E.coli |
Tag Info |
N-terminal GST-tagged |
MW |
48.4 kDa |
Relevance |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . Down-regulates activation of NF-kappa-B. |
Reference |
COMMD proteins, a novel family of structural and functional homologs of MURR1.Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S.J. Biol. Chem. 280:22222-22232(2005) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Form |
Liquid or Lyophilized powder |
Buffer |
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes |
Subcellular Location |
Cytoplasm, Nucleus |
Tissue Specificity |
Ubiquitous. |
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