Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Menge |
200ug |
Host |
E.coli |
ArtNr |
CSB-RP060054h-200 |
Konjugat/Tag |
GST |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Research Topic |
Cardiovascular |
Uniprot ID |
P29965 |
Gene Names |
CD40LG |
Organism |
Homo sapiens (Human) |
AA Sequence |
HRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSL LNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKG DQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNN LVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQ APFIASLCLKSPGRFERILLRAANTHSSAKPCGQQ SIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSF GL |
Expression Region |
47-258aa |
Sequence Info |
Extracellular Domain |
Source |
E.coli |
Tag Info |
N-terminal GST-tagged |
MW |
50.8 kDa |
Alternative Name(s) |
T-cell antigen Gp39TNF-related activation protein ; TRAPTumor necrosis factor ligand superfamily member 5; CD154 |
Relevance |
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. |
Reference |
Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome.Seyama K., Nonoyama S., Gangsaas I., Hollenbaugh D., Pabst H.F., Aruffo A., Ochs H.D.Blood 92:2421-2434(1998) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Cytokine that binds to CD40/TNFRSF5 |
Involvement in disease |
Immunodeficiency with hyper-IgM, type 1 (HIGM1) |
Subcellular Location |
Cell membrane, Single-pass type II membrane protein, Cell surface, SUBCELLULAR LOCATION: CD40 ligand, soluble form: Secreted |
Protein Families |
Tumor necrosis factor family |
Tissue Specificity |
Specifically expressed on activated CD4+ T-lymphocytes. |
Paythway |
NF-kappaBsignalingpathway |
Tag Information |
N-terminal GST-tagged |
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