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Recombinant Human Neuroserpin protein(SERPINI1) (Active)

Recombinant Human Neuroserpin protein(SERPINI1) (Active)

ArtNr	CSB-AP000141HU-5
Hersteller	Cusabio
Menge	5 ug
Quantity options	1 mg 100 ug 25 ug 250 ug 5 ug 500 ug
Kategorie	Food Safety Proteins Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins Glial Cell Markers
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>95% as determined by SDS-PAGE and HPLC.
Sequence	TGATFPEEAI ADLSVNMYNR LRATGEDENI LF SPLSIALA MGMMELGAQG<br/>STQKEIRHSM GYDS LKNGEE FSFLKEFSNM VTAKESQYVM KIANSL FVQN<br/>GFHVNEEFLQ MMKKYFNAAV NHVDFSQN VA VANYINKWVE NNTNNLVKDL<br/>VSPRDFDAAT YLALINAVYF KGNWKSQFRP ENTRTFSFTK D DESEVQIPM<br/>MYQQGEFYYG EF
Protein Familie	Serpin family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Peptidase inhibitor 12, Serpin I1
Lieferbar
Manufacturer - Category	Enzyme / Enzyme
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	44.7 kDa
General Research Areas	Neuroscience
Relevance	Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
Function	Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin
Subcellular Location	Secreted, Cytoplasmic vesicle, secretory vesicle lumen, Perikaryon
Tissue Specificity	Detected in brain cortex and hippocampus pyramidal neurons (at protein level) (PubMed:17040209). Predominantly expressed in the brain (PubMed:9070919).
Involvement in disease	Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB)
Gene Names	SERPINI1, PI12
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.5 , lyophilized
Uniprot Entry Name	NEUS_HUMAN
Expression Region	17-406aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.5 ug/ml, corresponding to a specific activity of > 2000 IU/mg.
PubMed ID	9070919; 14702039; 17974005; 15489334; 10517635

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CSB-AP000141HU-5-datasheet.pdf

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Menge: 5 ug

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Lieferung vsl. bis 30.10.2025

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