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Recombinant Human Interleukin-33 protein(IL33) (Active)

Recombinant Human Interleukin-33 protein(IL33) (Active)

ArtNr	CSB-AP001911HU-2
Hersteller	Cusabio
Menge	2 ug
Quantity options	1 mg 10 ug 100 ug 2 ug 250 ug 500 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>97% as determined by SDS-PAGE and HPLC.
Sequence	SITGISPIT EYLASLSTYN DQSITFALED ESY EIYVEDL KKDEKKDKVLLSYYESQHPS NE SGD GVDGK MLMVTLSPTK DFWLHANNKE HSVELHK CEKPLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET
Protein Familie	IL-1 family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-33, IL-1F11, Nuclear factor from high endothelial venules, NF-HEV,
Lieferbar
Manufacturer - Category	Cytokine / Interleukin
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	17.9 kDa
General Research Areas	Immunology
Relevance	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269\|PubMed:16286016, ECO:0000269\|PubMed:17853410, ECO:0000269\|PubMed:18836528}.; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100). {ECO:0000269\|PubMed:18787100, ECO:0000269\|PubMed:21734074}.
Function	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells
Subcellular Location	Nucleus, Chromosome, Cytoplasmic vesicle, secretory vesicle, Secreted
Tissue Specificity	Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
Paythway	Necroptosis
Gene Names	IL33, C9orf26, IL1F11, NFHEV
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2um filtered 20 mM PB, 150 mM NaCl, 1mM EDTA, pH7.4 , lyophilized
Uniprot Entry Name	IL33_HUMAN
Expression Region	112-270aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.05 ng/ml, corresponding to a specific activity of ? 2.0 x 107 IU/mg.
PubMed ID	12819012; 10566975; 16286016; 21454686; 14702039; 15164053; 15489334; 22307629; 17853410; 17185418; 18787100; 18836528; 19596270; 19559631; 19465481; 19439663; 21734074; 22215666; 19836339; 23980170

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CSB-AP001911HU-2-datasheet.pdf

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Menge: 2 ug

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Lieferung vsl. bis 18.09.2025

Express-Lieferung: 3 Tage sparen

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