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Recombinant Human Insulin-like growth factor I protein(IGF1) (Active)

Recombinant Human Insulin-like growth factor I protein(IGF1) (Active)

ArtNr	CSB-AP002521HU-20
Hersteller	Cusabio
Menge	20 ug
Quantity options	1 mg 100 ug 20 ug
Kategorie	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>97% as determined by SDS-PAGE and HPLC.
Sequence	TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SS RRAPQTGI VDECCFRSCD LRRLEMYCAP LKPA KSA
Protein Familie	Insulin family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IGF-I, MGF, Somatomedin-C
Lieferbar
Manufacturer - Category	Cytokine / Growth Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	7.4 kDa
General Research Areas	Cancer
Relevance	The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. {ECO:0000269\|PubMed:21076856, ECO:0000269\|PubMed:24132240}.
Function	The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation
Subcellular Location	Secreted
Involvement in disease	Insulin-like growth factor I deficiency (IGF1 deficiency)
Paythway	HIF-1signalingpathway
Gene Names	IGF1, IBP1
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name	IGF1_HUMAN
Expression Region	52-118aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 x 105 IU/mg.
PubMed ID	6358902; 3002851; 2935423; 2937782; 3455760; 2082190; 2018498; 1372070; 8495408; 16541075; 15489334; 6382022; 632300; 3242681; 21076856; 24132240; 6189745; 2036417; 1319992; 8857020; 10391209

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CSB-AP002521HU-20-datasheet.pdf

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Menge: 20 ug

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Lieferung vsl. bis 09.10.2025

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