Recombinant Human Peroxisome proliferator-activated receptor alpha(PPARA)

N-terminal 10xHis-tagged and C-terminal Myc-tagged

56.2 kDa

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.

Nucleus

cAMPsignalingpathway

Full Length

Tris-based buffer, 50% glycerol