Recombinant Human Protein cereblon(CRBN)

Neuroscience

Not Test

Homo sapiens(Human)

MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVED QDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGR TLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQ EVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAE IYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSD GIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPS KPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLY SLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDF SYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIM NKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYV NPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYA WTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS ALLPTIPDTEDEISPDKVILCL

1-442aa

64.5 kDa

"The DNA sequence, annotation and analysis of human chromosome 3."Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. Gibbs R.A.Nature 440:1194-1198(2006)

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.

Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

Cytoplasm, Nucleus, Membrane, Peripheral membrane protein

Widely expressed. Highly expressed in brain.