Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Menge |
10ug |
Host |
E.coli |
ArtNr |
CSB-EP010808HU-10 |
Konjugat/Tag |
Myc |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Research Topic |
Signal Transduction |
Uniprot ID |
P08238 |
Gene Names |
HSP90AB1 |
Organism |
Homo sapiens (Human) |
AA Sequence |
PEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNK EIFLRELISNASDALDKIRYESLTDPSKLDSGKEL KIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIA KSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAE KVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIG RGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGY PITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEE KPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEE LNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHL AVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKN NIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDL PLNISREMLQQSKILKVIRKNIVKKCLELFSELAE DKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLR YHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESK EQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLK EFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFE NLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTY GWTANMERIMKAQALRDNSTMGYMMAKKHLEINPD HPIVETLRQKAEADKNDKAVKDLVVLLFETALLSS GFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPN AAVPDEIPPLEGDEDASRMEEVD |
Expression Region |
2-724aa |
Sequence Info |
Full Length of Mature Protein |
Source |
E.coli |
Tag Info |
N-terminal 10xHis-tagged and C-terminal Myc-tagged |
MW |
88.1 kDa |
Alternative Name(s) |
Heat shock 84KDA |
Relevance |
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. |
Reference |
"Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens." Hoffmann T., Hovemann B. Gene 74:491-501(1988) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function |
Subcellular Location |
Cytoplasm, Melanosome, Nucleus, Secreted, Cell membrane |
Protein Families |
Heat shock protein 90 family |
Paythway |
Estrogensignalingpathway |
Tag Information |
N-terminal 10xHis-tagged and C-terminal Myc-tagged |
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