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Recombinant Rat Atrial natriuretic peptide receptor 3(Npr3),partial

Recombinant Rat Atrial natriuretic peptide receptor 3(Npr3),partial

Hersteller	Cusabio
Kategorie	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Peptides & Proteins Recombinant Proteins Calcium Binding Protein Markers
Typ	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Menge	1mg
Host	E.coli
ArtNr	CSB-EP016025RA1-1
eClass 6.1	34160400
eClass 9.0	42020190
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Research Areas	Others
Uniprot ID	P41740
Gene Names	Npr3
Organism	Rattus norvegicus (Rat)
AA Sequence	EALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYAL RSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFS LVDRVAAARGAKPDLILGPVCEYAAAPVARLASHW DLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMG EMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGV HEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSE RVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIE LFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLL RTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEG FHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNR TFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQE VIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIV EHTNSSPCKSCGLEESA
Expression Region	41-477aa
Sequence Info	Extracellular Domain
Source	E.coli
Tag Info	N-terminal 6xHis-SUMO-tagged
MW	64.9 kDa
Alternative Name(s)	Atrial natriuretic peptide clearance receptorAtrial natriuretic peptide receptor type C ; ANP-C ; ANPR-C ; NPR-C
Relevance	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity .
Reference	A single residue determines the distinct pharmacology of rat and human natriuretic peptide receptor-C.Engel A.M., Schoenfeld J.R., Lowe D.G.J. Biol. Chem. 269:17005-17008(1994)
Purity	Greater than 90% as determined by SDS-PAGE.
Form	Liquid or Lyophilized powder
Buffer	If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Subcellular Location	Membrane, Single-pass type I membrane protein
Protein Families	ANF receptor family
Tag Information	N-terminal 6xHis-SUMO-tagged

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CSB-EP016025RA1-1-datasheet.pdf

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