Vergleich

Recombinant Human Acidic mammalian chitinase(CHIA)

ArtNr CSB-EP874858HU-50
Hersteller Cusabio
Menge 50 ug
Quantity options 1 mg 10 ug 100 ug 20 ug 200 ug 50 ug 500 ug
Kategorie
Typ Proteins Recombinant
Specific against other
Host E.coli
Konjugat/Tag GST
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPG SRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRL MVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYD LHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMN YWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGA PTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGW DAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNK FGG
Protein Familie Glycosyl hydrolase 18 family, Chitinase class II subfamily
Citations "Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member."
Saito A., Ozaki K., Fujiwara T., Nakamura Y., Tanigami A.
Gene 239:325-331(1999)
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Lung-specific protein TSA1902
Lieferbar
Manufacturer - Conjugate / Tag
N-terminal GST-tagged
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Molecular Weight
67.1 kDa
Buffer
Tris-based buffer, 50% glycerol
General Research Areas
Immunology
Relevance
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
Expression Region
1-368aa
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
Subcellular Location
Isoform 1: Secreted
Tissue Specificity
Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.
Gene Names
CHIA
Sequence Info
Full Length of Isoform 2
Organism
Homo sapiens (Human)
Manufacturer - Format
Liquid or Lyophilized powder

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
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