Vergleich

Recombinant Human Extracellular serine/threonine protein kinase FAM20C(FAM20C)

ArtNr CSB-MP816901HU-50
Hersteller Cusabio
Menge 50 ug
Quantity options 10 ug 100 ug 1 mg 20 ug 50 ug
Kategorie
Typ Proteins Recombinant
Specific against other
Host Mammalian cells
Konjugat/Tag Myc, HIS
Purity Greater than 90% as determined by SDS-PAGE.
Sequence DFSSDPSSNLSSHSLEKLPPAAEPAERALRGRDPG ALRPHDPAHRPLLRDPGPRRSESPPGPGGDASLLA RLFEHPLYRVAVPPLTEEDVLFNVNSDTRLSPKAA ENPDWPHAGAEGAEFLSPGEAAVDSYPNWLKFHIG INRYELYSRHNPAIEALLHDLSSQRITSVAMKSGG TQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYF SDYERHNAEIAAFHLDRILDFRRVPPVAGRMVNMT KEI
Protein Familie FAM20 family
Citations "A single kinase generates the majority of the secreted phosphoproteome."
Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J., Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N., Pinna L.A., Pagliarini D.J., Dixon J.E.
Cell 161:1619-1632(2015)
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Dentin matrix protein 4 (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK) (DMP4)
Lieferbar
Manufacturer - Conjugate / Tag
N-terminal 10xHis-tagged and C-terminal Myc-tagged
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Molecular Weight
61.4 kDa
Relevance
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion
Expression Region
93-584aa
Protein Length
Full Length of Mature Protein
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth
Subcellular Location
Secreted, Golgi apparatus
Tissue Specificity
Widely expressed.
Involvement in disease
Raine syndrome (RNS)
Biological activity
Not Test
Manufacturer - Format
Liquid or Lyophilized powder

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
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