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Mouse CXCR3 Full Length Protein (VLP)

Mouse CXCR3 Full Length Protein (VLP)

ArtNr	CX3-M52P7-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 20 ug 250 ug x 2
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid
Specific against	Mouse (Murine, Mus musculus)
Host	HEK293
Konjugat/Tag	Unconjugated
Dry ice	Yes
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Versandbedingung	Trockeneis
Lieferbar
Manufacturer - Category	Protein
Shipping Temperature	Dry ice
Storage Conditions	-70°C
Molecular Weight	43.9 kDa \| 56.1 kDa
Manufacturer - Format	Liquid
Description	Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.
Background	Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.
Molecule	CXCR3
Exp Region	Tyr 2 - Leu 367
Characteristics	This protein .
Endotoxin	1.0 EU per μg
Buffer	PBS, Arginine, pH7.4
Stability	● The product MUST be stored at -70°C or lower upon receipt ● -70°C for 12 months under sterile conditions.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

CX3-M52P7-100ug-datasheet.pdf

CX3-M52P7-100ug-safety-datasheet.pdf