HSD11B2 Polyclonal Antibody

HSD11B2

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

IHC 1:50-1:200

HSD11B2

Synthetic peptide of human HSD11B2