CASP10 Polyclonal Antibody

CASP10

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

IHC 1:25-1:100

CASP10

Recombinant protein of human CASP10