TIRAP Polyclonal Antibody

TIRAP

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

IHC 1:25-100

TIRAP

Full length fusion protein