CASP4 Polyclonal Antibody

CASP4

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is " caspase 4, apoptosis-related cysteine peptidase" , this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

IHC 1:30-1:150

Polyclonal

Polyclonal Antibodies