FAS Polyclonal Antibody

FAS

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

45kDa

Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

WB 1:500-1:1000; IHC 1:50-1:100

FAS

Recombinant Human Tumor necrosis factor receptor superfamily member 6 protein