PSEN1 Polyclonal Antibody

PSEN1

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

52kDa

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

WB 1:500-1:2000; IHC 1:50-1:200

Polyclonal

Polyclonal Antibodies