BAG3 Polyclonal Antibody

BAG3

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

80kDa

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

IHC 1:50-1:100

Polyclonal

Polyclonal Antibodies