LIMK1 Polyclonal Antibody

LIMK1

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

IHC 1:50-1:200

LIMK1

Synthetic peptide of human LIMK1