STAT1 Polyclonal Antibody

Stat1

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

87kDa

Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:50-1:200

Stat1

Synthesized peptide derived from human Stat1 around the non-phosphorylation site of Ser727.