PHOX2B Polyclonal Antibody

Store at -20C. Avoid freeze / thaw cycles.

32kDa

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4

WB1:500 - 1:2000 IHC1:50 - 1:200