« Zurück
Startseite /
Recombinant Human IL6RA/CD126 Protein (His Tag)

Recombinant Human IL6RA/CD126 Protein (His Tag)

ArtNr	ELS-PKSH031632-50ug
Hersteller	Elabscience
Menge	50 ug
Quantity options	100 ug 50 ug 1 mg
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis By Cell Type Carcinoma Hematology Leukemia Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis
Typ	Proteins
Format	Lyophilized Powder
Applikationen	ELISA, Cell Culture
Specific against	Human (Homo sapiens)
Host	HEK293 cells
Konjugat/Tag	HIS
Purity	> 90 % as determined by reducing SDS-PAGE.
Sequence	Met 1-Pro 365
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Membrane glycoprotein, CD126, gp80, IL6Q, IL-6R, IL-6R 1, IL-6R subunit alpha, IL-6R-1, IL6RA, IL-6RA, IL-6R-Alpha, IL6RQ, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80, IL6R, IL-6R&amp, alpha, alpha, CD 126, CD126 antigen, IL 6R, IL 6R 1, IL 6R alpha, IL-6 receptor alpha chain, IL-6 receptor subunit alpha, IL-6R 1 Membrane glycoprotein 80 (gp80), Interleukin 6 receptor, MGC30256
Similar products	IL-6R, CD126, IL-6R-1, IL-6R-alpha, gp80, IL-6RA, Membrane glycoprotein 80, IL-6R 1, IL-6R subunit alpha, Interleukin-6 receptor subunit alpha, IL6Q, IL6RQ
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Category	Recombinant Proteins / Others
Manufacturer - Conjugate / Tag	C-His
Shipping Temperature	This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight	40 kDa
Manufacturer - Research Areas	immunology, Stem cells
Background	Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
Abbreviation	IL6RA/CD126
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution	Please refer to the printed manual for detailed information.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Activity	1. Immobilized recombinant human IL-6 at 8 μg/mL (100μl/well) can bind recombinant human IL6R with a linear range of 1. 25-20.0 ng/ml. 2. Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/ml.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

ELS-PKSH031632-50ug-datasheet.pdf

ELS-PKSH031632-50ug-safety-datasheet.pdf