Recombinant Human PD-L1/B7-H1/CD274 Protein (His Tag)(Active)

This product is provided as lyophilized powder which is shipped with ice packs.

35-38 kDa

Programmed death-1 ligand-1 (PD-L1; CD274; B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain; and together with PD-L2; are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells; PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly; it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.Immune CheckpointImmune Checkpoint Blockade: Blocking Antibodies      Immune Checkpoint Blockade: PD-L1 / B7-H1 / CD274 Blocking AntibodiesImmune Checkpoint Detection: Antibodies      Immune Checkpoint Detection: ELISA Antibodies      Immune Checkpoint Detection: IHC Antibodies      Immune Checkpoint Detection: ICC Antibodies      Immune Checkpoint Detection: FCM Antibodies      Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint Proteins      PD-L1 / B7-H1 / CD274 Immune Checkpoint ProteinsImmune Checkpoint Targets      Co-inhibitory Immune Checkpoint Targets Immunotherapy      Cancer Immunotherapy      Targeted Therapy

Please refer to the printed manual for detailed information.

Measured by its binding ability in a functional ELISA. Immobilized human B7-H1 at 20 ug/ml (100 ul/well) can bind human PD1 with a linear ranger of 0.032-0.8 ug/ml.