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Recombinant Human FGF-10/FGF10 Protein

ArtNr ELS-PKSH032432-10ug
Hersteller Elabscience
Menge 10 ug
Quantity options 10 ug 50 ug
Kategorie
Typ Proteins
Format Lyophilized Powder
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag Untagged
Purity > 95 % as determined by reducing SDS-PAGE.
Sequence Gln38-Ser208
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias FGF-10, FGF10, Fibroblast growth factor 10, KGF-2, KGF2, Keratinocyte growth factor 2
Similar products FGF10, Fibroblast growth factor 10, Keratinocyte growth factor 2, FGF-10, KGF-2, KGF2
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Category
Recombinant Proteins / Cytokines
Manufacturer - Conjugate / Tag
None
Shipping Temperature
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
19.5 kDa
Observed Molecular Weight
19-22 kDa
Manufacturer - Research Areas
Signal Transduction, Cardiovascular, Cancer, Stem cells
Background
Fibroblast growth factor 10 (FGF-10, KGF-2), is a member of the fibroblast growth factor (FGF) family that includes FGF-3, -7, and -22. KGF-2 is secreted by mesenchymal cells and associates with extracellular FGF-BP. It preferentially binds and activates epithelial cell FGFR2 and interacts more weakly with FGFR1. It plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. It exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 is required for normal branching morphogenesis. Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG). ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
Abbreviation
FGF-10; FGF10
Endotoxin
< 0.01 EU per μg of the protein as determined by the LAL method.
Reconstitution
Please refer to the printed manual for detailed information.
Formulation
Lyophilized from a 0.2 μm filtered solution of 10mM Tris, 5% Sucrose, 4% Mannitol, 0.02% Tween 80, pH8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Activity
Not validated for activity

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10 ug
Lieferbar: In stock
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