Recombinant Mouse EGFR Protein (Fc Tag)

Recombinant Proteins / Cytokines

This product is provided as lyophilized powder which is shipped with ice packs.

96.0 kDa

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α , betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Please refer to the printed manual for detailed information.

Measured by its ability to bind human EGF in a functional ELISA.