Recombinant Mouse APCS/SAP Protein (His Tag)

Recombinant Proteins / Others

This product is provided as lyophilized powder which is shipped with ice packs.

25.3 kDa

Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called " amyloid" . Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.

Please refer to the printed manual for detailed information.

1. Immobilized mouse APCS at 10 μg/ml (100 μl/well) can bind biotinylated human Fibronectin Fragment 2 with a linear ranger of 0.625-5 μg/ml. 2. Measured by its ability to bind mouse CD64-AVI in a functional ELISA.