ClinMax™ Human IL-1β ELISA Kit

CRS Related Kits

ClinMax™Human IL-1β Quantitative ELISA Kit is designed to quantitate human IL-1β that is present in complex biological matrices, such as human serum, plasma, buffered solution, or cell culture.
Interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine. IL-1β is produced and secreted by various cell types, such as immune cells, fibroblasts, or cancer cells. The IL-1β gene is induced after "priming" of the cells and a second signal is required to allow IL-1β maturation by inflammasome-activated caspase-1. IL-1β is then released and leads to transcription of target genes through its ligation with IL-1R1 on target cells. IL-1β expression and maturation are guided by gene polymorphisms and by the cellular context. In cancer, IL-1β has pleiotropic effects on immune cells, angiogenesis, cancer cell proliferation, migration, and metastasis.