SMC1 Antibody

WB, IHC, IF, FC, ELISA.Not yet tested in other applications. Determining optimal working dilutions by titration test.

Store at 4C, for long term storage, store at -20C

Purified recombinant fragment of human SMC1 expressed in E. Coli.

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.

Ascitic fluid containing 0.03% sodium azide.