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Beta-Synuclein ELISA Kits (for human, mouse , rat ,canine)

ArtNr BSyn-ELISA
Hersteller Fivephoton
Menge 1 kit, 96 T
Kategorie
Typ Elisa-Kit
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Citations Giasson, B. I., Duda, J. E., Forman, M. S., Lee, V. M., & Trojanowski, J. Q. (2001). Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons. Experimental Neurology, 172(2), 354-362.

Lincoln, S., Crook, R., Chartier-Harlin, M. C., Gwinn-Hardy, K., Baker, M., Mouroux, V., Richard, F., et al. (1999). No pathogenic mutations in the beta-synuclein gene in Parkinson’s disease. Neuroscience Letters, 269(2), 107-109.

Ohtake, H., Limprasert, P., Fan, Y., Onodera, O., Kakita, A., Takahashi, H., Bonner, L. T., et al. (2004). Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology.

Rivers, R. C., Kumita, J. R., Tartaglia, G. G., Dedmon, M. M., Pawar, A., Vendruscolo, M., Dobson, C. M., et al. (2008). Molecular determinants of the aggregation behavior of alpha- and beta-synuclein. Protein Science, 17(5), 887-898. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT.

Yamin, G., Munishkina, L. A., Karymov, M. A., Lyubchenko, Y. L., Uversky, V. N., & Fink, A. L. (2005). Forcing nonamyloidogenic beta-synuclein to fibrillate. Biochemistry, 44(25), 9096-107.
ECLASS 10.1 32160605
ECLASS 11.0 32160605
UNSPSC 41116126
Gefahren-Info Sodium Azide (0.1%)
Lieferbar
Manufacturer - Targets
SNCB
Storage Conditions
4°C
Description
Highlights: Dynamic assay range 300pg/ml - 60ng/ml for human SNCB, Separate kits are available for human, mouse and rat beta-synuclein. Highly selective to beta-syncuclein (SNCB) with insignificant cross-reactivity to other synucleins. Sandwich ELISA format providing convenience and high sensitivity. Strip plate format allowing separate assay and storage of sections. Rapid protocol: Only one incubation with antibodies. Total protocol time approximately 1.5 hrs. Colormetric detection at 450nm using a standard absorbance plate reader.

Poisonous Material
Sodium Azide (0.1%)
Background
Beta-Synuclein, a member of the synucelin family of proteins, is highly homologous to alpha-synuclein. Beta-synuclein is highly expressed in the substantia nigra, a region of neuronal degeneration in patients with Parkinson's disease; however, no direct relationship to Parkinson's disease has been established. Beta-synuclein is predominantly expressed in the neocortex, hippocampus, striatum, thalamus, and cerebellum. Beta-synuclein may inhibit alpha-synuclein aggregation, which occurs in Parkinson's disease. Thus, beta-synuclein may provide protection from the toxicity associated with alpha-synuclein aggregation.
Highlights
Separate kits are available for human, mouse and rat beta-synuclein.
Sandwich ELISA format providing convenience and high sensitivity.
Strip plate format allowing separate use and storage of sections of the ELISA plate.
pg/ml detection

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 1 kit, 96 T
Lieferbar: In stock
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