Rabbit Amyloid-Beta (1 - 40) ELISA Assay Kit, 96T

APP

Amyloid-Beta (Abeta) is generated by sequential cleavage of the amyloid precursor protein (APP) by beta and gamma secretases. The gamma secretase, which produces the C-terminal end of the Abeta peptide, cleaves within the transmembrane region of APP and generates amyloid-Beta (Abeta) isoforms of 36-43 amino acid residues in length. The predominant isoforms of amyloid-Beta are Abeta40 and Abeta42. The shorter amyloid-Beta isoform is typically produced by cleavage in the endoplasmic reticulum, while the longer isoform is processed by cleavage in the trans-Golgi network. Abeta40 is the most common amyloid-Beta (Abeta) isoform, but Abeta42 is more fibrillogenic and is thus the predominant form associated Alzheimer’s disease. Antibodies employed in this Amyloid-Beta ELISA kit are selective for the Abeta40 isoform of amyloid-beta, with insignificant cross-reactivity to the Abeta42 isoform.