Sodium Orthovanadate

ArtNr	ACTVO-4-30
Hersteller	Fivephoton
CAS-Nr.	13721-39-6
Menge	30 ml
Quantity options	12 ml 20 ml 30 ml 50 ml 6 ml
Kategorie	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Reagents & Chemicals Molecules By Organ Bladder Cancer Colorectal Cancer
Typ	Molecules
Specific against	other
Citations	Feng Y, Bhatt AJ, Fratkin JD, and Rhodes PG. Neuroprotective effects of sodium orthovanadate after hypoxic-ischemic brain injury in neonatal rats Brain Res Bull 76: 102-108, 2008. Hasegawa Y, Morioka M, Hasegawa S, Matsumoto J, Kawano T, Kai Y, Yano S, Fukunaga K, and Kuratsu J. Therapeutic time window and dose dependence of neuroprotective effects of sodium orthovanadate following transient middle cerebral artery occlusion in rats. J Pharmacol Exp Ther 317: 875-881, 2006. Hulley PA, Conradie MM, Langeveldt CR, and Hough FS. Glucocorticoid-induced osteoporosis in the rat is prevented by the tyrosine phosphatase inhibitor, sodium orthovanadate. Bone 31: 220-229, 2002. Kafl HE and Elkashef HA. Effect of sodium orthovanadate on the urinary bladder rings isolated from normal and hyperglycemic rats. Pak J Pharm Sci 19: 195-201, 2006. Klein A, Holko P, Ligeza J, and Kordowiak AM. Sodium orthovanadate affects growth of some human epithelial cancer cells (A549, HTB44, DU145). Folia Biol (Krakow) 56: 115-121, 2008. Li L, Eisen AZ, Sturman E, and Seltzer JL. Protein tyrosine phosphorylation in signalling pathways leading to the activation of gelatinase A: activation of gelatinase A by treatment with the protein tyrosine phosphatase inhibitor sodium orthovanadate. Biochim Biophys Acta 1405: 110-120, 1998. Matsumoto J, Morioka M, Hasegawa Y, Kawano T, Yoshinaga Y, Maeda T, Yano S, Kai Y, Fukunaga K, and Kuratsu J. Sodium orthovanadate enhances proliferation of progenitor cells in the adult rat subventricular zone after focal cerebral ischemia. J Pharmacol Exp Ther 318: 982-991, 2006. Milward AD, Riba R, Patel B, Oberprieler NG, and Naseem KM. Sodium orthovanadate induced tyrosine phosphorylation of platelet nitric oxide synthase negatively regulates enzyme activity. Biochim Biophys Acta 1760: 1411-1417, 2006. Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita M, Suzuki T, Ohtomo K, and Hosoi Y. Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. Cell Death Differ 13: 499-511, 2006. Pelassy C, Breittmayer JP, and Aussel C. Inhibition of phosphatidylserine synthesis during Jurkat T cell activation. The phosphatase inhibitor, sodium ortho-vanadate bypasses the CD3/T cell receptor-induced second messenger signaling pathway. Eur J Biochem 267: 984-992, 2000. Preet A, Siddiqui MR, Taha A, Badhai J, Hussain ME, Yadava PK, and Baquer NZ. Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biochemical abnormalities in diabetic rat ocular tissues. Mol Cell Biochem 289: 137-147, 2006. Tran NP, Park JK, Hong SJ, and Lee CG. Proteomics of proteins associated with astaxanthin accumulation in the green algae Haematococcus lacustris under the influence of sodium orthovanadate. Biotechnol Lett 31: 1917-1922, 2009. Ueki H, Yamasaki Y, Higo K, Motoyashiki T, Kawabata H, and Morita T. Regulation of cyclic AMP phosphodiesterase activity by particulate protein tyrosine kinase and phosphotyrosine phosphatase activities sensitive to sodium orthovanadate. Biol Pharm Bull 18: 214-218, 1995. Wo YY, Sheu DS, and Lu CH. Sodium vanadate treatment as a shortcut following alkaline phosphatase cleavage. Biotechniques 25: 350-352, 1998. Wu DN, Pei DS, Wang Q, and Zhang GY. Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus. Neurosci Lett 404: 98-102, 2006.
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Lieferbar
Storage Conditions	-20°C
Description	Highlights Pre-activated, depolymerized and ready-to-use: 200 mM sodium orthovanadate (vanadate) solution in dH20, pH10. Formulated by depolymerization with a pH-boiling cycle until colorless at pH 10.0. >99% sodium orthovanadate stock starting material. Potent tyrosyl, alkaline phosphatase inhibitor and ATPase inhibitor. Dispense sodium orthovanadate directly into cell lysates, or add to culture cells. Soluble in physiological buffers.
Background	Sodium Orthovanadate (Part ACTVO-4) is provided as a potent phosphatase inhibitor that has been pre-activated by a pH10 adjustment and boiling cycle until the solution maintains a colorless appearance at equilibrium at pH10§. This preparation depolymerizes sodium orthovanadate and enhances its potency as an inhibitor of phosphotyrosyl phosphatases. This activated sodium orthovanadate solution is ready-to-use and can be diluted directly into cell lysates or cell culture medium (after sterilization). Pre-activated sodium orthovanadate solution is stable for at least one year when stored at -20C. Certain buffer components such as EDTA and oxidants interact with inhibition potency: HEPES is a preferred buffer to maintain vanadate potency.
Highlights	Formula: Na3VO4 CAS Number: 13721-39-6 Provided concentration: 200 mM Purity: Starting material: >99% vanadate solid stock Molecular Weight: 183.9 Solubility in water: soluble Appearance: colorless, clear solution (in dH20, pH10) Pre-activated through depolymerization at pH 10.0 with a pH-boiling cycle until colorless at equilibrium Experimental concentration: 1 mM Inhibition reversed by EDTA, DTT Shipped at ambient temperature Storage: Aliquot; -20C. (After defrosting, vortex to solubilize crystals). Stable at -20C for at least one year.

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Menge: 30 ml

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