Amyloid Precursor Protein Antibody (653-662), pAb, Rabbit

USA

GenScript Rabbit Anti-APP (653-662) Polyclonal Antibody can detect both human recombinant APP and endogenous APP from cell lysates and tissue slides and mouse APP in brain tissue lysate.

Amyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP is found in three main isoforms, APP695, APP751, and APP770. APP can be sequentially cleaved by beta-secretase and gamma-secretase to release beta-amyloid, which is the main component of senile plaque the brains of patients afflicted with Alzheimers disease. GenScript Rabbit Anti-APP (653-662), Polyclonal Antibody is developed in rabbit hosts using a synthetic peptide, RPGSGLTNIK, corresponding to C terminal amino acids 653-662 of human APP. GenScript Rabbit Anti-APP (653-662) Polyclonal Antibody is a valuable tool for scientists and neuropathologists who study the role of APP in Alzheimer’s disease. GenScript Rabbit Anti-APP (653-662) Polyclonal Antibody is highly purified from rabbit antiserum by immunoaffinity chromatography.

Immunoaffinity chromatography