Amyloid Precursor Protein Antibody (747-761), pAb, Rabbit

USA

GenScript Rabbit Anti-APP (747-761) Polyclonal Antibody is specific to human APP.

Amyloid precursor protein (APP) is a type I integral membrane protein with a large N-terminal extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. APP is found as three main isoforms, APP695, APP751 and APP770. APP can be sequentially cleaved by beta-secretase and gamma-secretase to release beta-amyloid, which is the main component of senile plaque in patient brains inflicted with Alzheimers disease. GenScript, Rabbit Anti-APP (747-761) Polyclonal Antibody, is developed in rabbit using a synthetic peptide, RHLSKMQQNGYENPT, corresponding to the C term amino acids 747-761 of human APP. GenScript Rabbit anti APP (747-761) Polyclonal Antibody should be a valuable tool for scientists and neuropathologists who study the role of APP in Alzheimer’s disease. Rabbit Anti-APP (747-761) Polyclonal Antibody is highly purified from rabbit antiserum by immunoaffinity chromatography and is supplied as a 40 ug aliquot at a concentration of 0.5 mg/ml.

Immunoaffinity chromatography